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BID 500 (Cefadroxil 500mg)
Product Code: BID001
Made in: Ấn
Description:
ACTIVE ELEMENTS
Cefadroxil: antibiotic
MECHANISM OF ACTION
Cefadroxil: inhibits the synthesis of cell wall
INDICATIONS
Upper and lower respiratory tract infections, urinary tract infections, osteitis and arthritis
ADVANTAGE
Good tolerance, few side-effect
Rarely causes intestinal dysmicrobia.
LEAFLET
Read the leaflet carefully before use
For further information, consult with your physician
The medicine is under prescription only
BID–500 CAPSULE
(Cefadroxil Capsules USP 500mg)
[COMPOSITION]
Each capsule contains
Cefadroxil USP equivalent to Cefadroxil (anhydrous) 500.00 mg
Excipients (Talc, Magnesium Stearate, Colloidal Silicon dioxide)
[APPEARANCE]
Size “0” hard capsules, cap: dark blue, body: light blue, with BID–500 printed on both body and cap of capsule and containing white powder.
[PHARMACOLOGY]
Cefadroxil is a first–generation cephalosporin antibiotic. It is bactericidal, and acts by inhibiting synthesis of the bacterial cell wall. Bacterial cell walls are held rigid and protected against osmotic rupture by peptidoglycan. Cefadroxil inhibits the final cross–linking stage of peptidoglycan production by binding to and inactivating transpeptidase, which is a penicillin binding protein on the inner surface of the bacterial cell membrane. Cefadroxil is most active against Gram–positive cocci, and has moderate activity against Gram–negative bacilli. Sensitive Gram–positive cocci include penicilinase and non–penicilinase producing staphylococci. Some Gram–positive anaerobes are sensitive. Gram–negative bacteria include strains of Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Salmonella, and Shigella spp. It is active against Haemophilus influenzae.
[INDICATIONS]
Susceptibility
Susceptible: Methicilline sensitive Staphylococci, Streptococci with Penicilline sensitive Branhamella catarrhalis, Nesseria gonorrhoeae, Pasteurella, Corynebacterium diphtheriae, Propionibacterium acnes.
Moderately Susceptible: Haemophilus influenzae, Salmonella, Shigella, Citrobacter diversus, Proteus mirabilis, Clostridium perfrigens, Peptostreptococccus sp.
Cefadroxil is indicated for the treatment of infection caused by susceptible strains: Urinary tract infection particularly lower urinary tract infection, Skin and skin structure infections, Ear, Nose and throat infections: Pharyngitis and tonsillitis, sinusitis, otitis. Upper and lower respiratory tract infections.
[CONTRAINDICATIONS]
Cefadroxil Monohydrate is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
[SIDE EFFECTS]
Nausea and vomiting have been reported rarely. Diarrhea has also occurred. Other reaction have included genital pruritus, genital moniliasis, vaginitis. Some times it caused anaphylaxis, erythema multiforme, toxic epidermal necrolysis, fever, abdominal pain, superinfection, renal dysfunction, toxic nephropathy, hepatic dysfunction including cholestasis, aplastic anemia, hemolytic anemia, hemorrhage.
Immediately inform your physician of the side effects, if any.
[WARNINGS]
Before starting therapy check the hypersensitivity reaction to cefadroxil. If an allergic reaction is occurs, discontinued the drug and consult with physician.
Do not administer if the medicine expired or the capsule melted and/ or the color changed.
The medecinr is under prescription only.
Keep out of reach of childreen.
[PRECAUTIONS]
In patients with known or suspected renal impairment, careful clinical observation and appropriate laboratory studies should be made prior to and during therapy.
[DRUG INTERACTIONS]
Positive direct Coombs tests have been reported during treatment with the cephalosporin antibiotics.
[DOSAGE]
Adult : 1g every 12 hours for usual infection, may be increased to 2g/12 hours for severe infections.
Pharyngitis and tonsilitis due to Streptococcus group A infection 0.5g every 12 hours or 1g/ once daily.
Children : 25 - 50mg / 1 kg every 12 hours, may be increased to 100 mg/kg/12 hours for severe infections.
In patients with known or suspected renal failure:
On the basis of Creatinine clearance
ClCRE 20 – 40 ml/min.: 1g/24 hours.
ClCRE 20 ml/min.: 1g/48 hours.
[SPECIFICATION]
USP.
[SHELF LIFE]
3 years from manufacturing date.
[STORAGE]
Store in a cool, dry place. Protect from light.
[PACKING UNIT]
10 tablets / blister; 10 blisters / paper box.
Manufactured by
KAPPAC PHARMA LIMITED
24, Dewan & Sons, Udyog Nagar,
Village Aliyali, Palghar – 401 404, INDIA
Tel : 0252–552805 Fax : 0252–55004 / 5301
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